The patient
A 70 year old retired barber presented to his general practitioner with breathlessness on walking. A history of gradual onset of fatigue, lethargy, and exertional dyspnoea was elicited.
The patient was a non-smoker who had previously been well, took no medications or supplements, and shared a bottle of wine with his wife at weekends. He was not a vegetarian and took a good mixed diet.
Physical examination showed pallor of the conjunctiva and nail beds and mild oedema of the ankles. There was no hepatosplenomegaly nor were there any signs of iron deficiency (such as glossitis, angular cheilosis, or koilonychia). Anaemia was suspected.
An initial full blood count confirmed this suspicion:
Hb concentration was 76 g/l (normal range 133-167 g/l),
MCV was 110 fl (82-98 fl),
white cell count was 4.7x109/l (3.7-9.5x109/l),
neutrophil count was 1.4x109/l (1.7-6.1x109/l), and
platelet count was 182x109/l (145-350x109/l).
Serum creatinine was 98 µmol/l (60-125 µmol/l) and
serum ferritin was 875 ng/ml (20-200 ng/ml).
What is the next investigation?
The clinical history has already excluded relevant drugs and
excessive alcohol intake. The following investigations should
be performed:
- A repeat full blood count to confirm the initial count and to establish if the abnormalities are stable or progressive.
- A peripheral blood film.Many laboratories will automatically review a blood film when the blood count is as abnormal as in this patient, but it cannot be assumed that the blood film will have been reviewed.
- Vitamin B-12 and folic acid assays.
- Reticulocyte count—will be raised in haemolysis or bleeding.
- Liver and thyroid biochemistry.
Identification of hypothyroidism, liver disease, or deficiency
of vitamin B-12 or folic acid in general practice avoids the
need to refer a patient to a haematologist. On the other hand,
referral is indicated if initial tests suggest haemolytic anaemia
or a myelodysplastic syndrome.
margin travels around the thoracic wall
following a VI, VIII, X contour
midaxillary line, and vertebra TX posteriorly).